Optimizing IVF Treatments

Supplementing Eggs With EggPCSM Mitochondria May Help to Enhance IVF Treatments


The discovery of EggPC cells helped identify an ideal source of mitochondria—energy-producing structures—within the outer protective lining of a woman’s ovaries. Mitochondria are the batteries fueling cell division and growth. In aging eggs and eggs with poor health, there is an insufficient number of functioning mitochondria, or sometimes the mitochondria present are damaged and unable to generate enough energy. Think of old batteries in a flashlight. Old batteries just don’t have enough energy to power the flashlight. But when you change the old batteries for new ones, the flashlight shines brightly once again!

IVF Success Directly Related to the Age and Health of Eggs

 

Recharging an egg’s energy level might improve IVF treatments.

Taking fresh mitochondria from your own EggPC cells and supplementing the existing mitochondria in your eggs could give your eggs the sufficient energy levels needed for embryo development.1-8

 

References:

  1. Hua S, Zhang Y, Li X, et al. Effects of granulosa cell mitochondria transfer on the early development of bovine embryos in vitro. Cloning and Stem Cells. 2007 June; 9(2): 237-246.
  2. Pinckert CA, Irwin M, Johnson L, Moffatt R. Mitochondria transfer into mouse ova by microinjection. Transgenic Res. 1997 Nov; 6 (6): 379-383.
  3. Yi YC. Chen MJ, Ho J, Guu HF, Ho E. Mitochondria transfer can enhance the murine embryo development. J Assist Reprod Genet. 2007 Oct; 24(10): 445–449.
  4. El Shourbagy SH, Spikings EC, Freitas, M, St John JC. Mitochondria directly influence fertilization outcome in the pig. Reproduction. 2006 Feb; 131(2): 233-245.
  5. Tzeng CR, Hsieh RH, Au HK, Yen YH, Chang SJ, Cheng YF. Mitochondria transfer (MIT) into oocyte from autologous cumulus granulosa cells (cGCs). Fertil Steril. 82(2): S53.
  6. Cohen J, Scott R, Alikani M, et al. Ooplasmic transfer in mature human oocytes. Mol Human Reprod. 1998 Mar; 4(3): 269-280.
  7. Lanzendorf, SE, Mayer J, Toner J, Oehninger S, Saffan DS, Muasher S. Pregnancy following transfer of ooplasm from cryopreserved-thawed donor oocytes into recipient oocytes. Fertil Steril. 1999 Mar; 71(3): 575-577.
  8. Levron J, Willadsen, S, Bertoli M, Cohen J. The development of mouse zygotes after fusion with synchronous and asynchronous cytoplasm. Hum Reprod. 1996 June; 11(6): 1287-1292.
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